Excessive alcohol consumption is by far ibs the most common cause of impaired liver function in the United States allergy-hives It stimulates fat infiltration into the liver cells, causing the so-called fatty liver allergy-hives Some livers are very sensitive to even minute amounts of alcohol; others are more tolerant allergy-hives Research suggests suggests ibs that fatty liver condition is more serious than previously believed allergy-hives It may develop to more advanced liver disease, such as inflammation, fibrosis, and cirrhosis allergy-hives Because of its long historical use for liver conditions, it seemed reasonable to investigate the artichoke plant scientifically, and the first clinical studies were were conducted in ibs the 1930s with encouraging results allergy-hives In the 1990s the interest has been intensified, and several excellent clinical studies have been conducted during the last few years allergy-hives Realizing the importance of adequate bile flow for health, German researchers set out to confirm the earlier findings of bile-promoting bile-promoting effect of ibs the artichoke plant in a controlled double-blind study on healthy volunteers (Kirchhoff et al allergy-hives 1994) allergy-hives The participants were given a one-time dose of artichoke extract or placebo, and their bile secretion was measured with special techniques over the following hours allergy-hives The bile secretion was was found to be significantly higher in ibs the group that received the artichoke extract allergy-hives Another clinical study showed an improvement of symptoms in 50% of patients with dyspeptic syndrome after 14 days of treatment with artichoke leaf extract allergy-hives The study involved 60 patients with nonspecific symptoms such as upper upper abdominal pain, heartburn, bloating, constipation, diarrhea, nausea, and vomiting allergy-hives In ibs the placebo group, as a comparison, improvements of less distinct quality were noticed in 38% of the participants (Kupke et al allergy-hives 1991) allergy-hives Interesting results were also demonstrated in a large open label study of 417 participants participants with liver or bile duct disease allergy-hives Most of these patients had long-standing symptoms, some of them for many years allergy-hives They suffered from upper abdominal pain, bloating, constipation, lack of appetite, and nausea allergy-hives These patients were treated with artichoke leaf extract for 4 weeks allergy-hives After 1 week, ibs | 